abstract：:Recently, SIRT5 was reported to be a predominant desuccinylase and demalonylase in mitochondria. Ablation of SIRT5 enhances the systemic succinylation and malonylation of mitochondrial proteins, including various metabolic enzymes; however, its function in pancreatic β cells has not yet been clarified. In this study, ...

journal_title：Experimental cell research

authors： Wang Y,Liu Q,Huan Y,Li R,Li C,Sun S,Guo N,Yang M,Liu S,Shen Z

更新日期：2018-10-01 00:00:00

abstract：:Multipotent mesenchymal stromal cells (MSCs) support wound healing processes. These cells express toll-like receptors (TLRs). TLRs perform important key functions when the immune system is confronted with danger signals. TLR ligation by lipopolysaccharides (LPS) activates MSCs and induces intracellular signaling casca...

journal_title：Experimental cell research

authors： Ruhl T,Kim BS,Beier JP

更新日期：2018-09-15 00:00:00

abstract：BACKGROUND:Metastatic and/or recurrent breast carcinomas are leading causes of cancer-related death worldwide. Breast cancer stem cells (BCSCs) have been implicated in cancer metastases and progression, thus, the need for the discovery and development of effective BCSCs-specific therapies against metastatic and triple ...

journal_title：Experimental cell research

authors： Chen JH,Kuo KT,Bamodu OA,Lin YC,Yang RB,Yeh CT,Chao TY

更新日期：2018-09-15 00:00:00

abstract：:The stimulatory heterotrimeric Gs protein alpha subunit (Gsα) is a ubiquitous guanine nucleotide-binding protein that regulates the intracellular cAMP signaling pathway and consequently participates in a wide range of biological events. In the reproductive system, despite Gsα being associated with oocyte meiotic arres...

journal_title：Experimental cell research

authors： Xie Y,Wu B,Jin Y,Zhang A,Sun X,Zhang X,Gao X,Dong R,Li H,Gao J

更新日期：2018-09-15 00:00:00

abstract：:Oxysterol-binding protein (OSBP)-related proteins (ORPs) are conserved lipid binding proteins found in organisms ranging from yeast to mammals. Recent findings have indicated that these proteins mainly localize to contact sites of 2 different membranous organelles. ORP6, a member of the ORP subfamily III, is one of th...

journal_title：Experimental cell research

authors： Mochizuki S,Miki H,Zhou R,Kido Y,Nishimura W,Kikuchi M,Noda Y

更新日期：2018-09-15 00:00:00

abstract：:Ischemia/reperfusion (I/R) injury, one of the leading health problems in the world, is defined as a cause of cardiomyocytes death. In the present study, we investigate the role of formyl peptide receptor 1 (FPR1) in cardiomyocyte apoptosis and ventricular remodeling of I/R injury rats and the underlying mechanism invo...

journal_title：Experimental cell research

authors： Zhou QL,Teng F,Zhang YS,Sun Q,Cao YX,Meng GW

更新日期：2018-09-15 00:00:00

abstract：:To study delayed genetic and epigenetic radiation effects, which may trigger radiation-induced carcinogenesis, we have established single-cell clones from irradiated and non-irradiated primary human fibroblasts. Stable clones were endowed with the same karyotype in all analyzed metaphases after 20 population doublings...

journal_title：Experimental cell research

authors： Flunkert J,Maierhofer A,Dittrich M,Müller T,Horvath S,Nanda I,Haaf T

更新日期：2018-09-15 00:00:00

abstract：:Tau pathology in Alzheimer's disease (AD) includes hyperphosphorylation and truncation of tau. Phosphorylation at S422 is found to suppress truncation of tau at D421 that leading to the generation of ΔTau. However, the interrelation between hyperphosphorylation and generation of ΔTau in AD remains elusive. In current ...

journal_title：Experimental cell research

authors： Cao L,Liang Y,Liu Y,Xu Y,Wan W,Zhu C

更新日期：2018-09-01 00:00:00

abstract：:Lysophosphatidic acid (LPA) signaling via G protein-coupled LPA receptors mediates various biological effects in cancer cells. This study aimed to investigate the roles of LPA receptors in the regulation of cellular functions during tumor progression in osteosarcoma cells. Long-term cisplatin (CDDP)-treated MG63-C and...

journal_title：Experimental cell research

authors： Takahashi K,Fukushima K,Tanaka K,Minami K,Ishimoto K,Otagaki S,Fukushima N,Honoki K,Tsujiuchi T

更新日期：2018-08-15 00:00:00

abstract：:An increase in tumour formation and metastasis are observed upon plakophilin3 (PKP3) loss. To identify pathways downstream of PKP3 loss that are required for increased tumour formation, a gene expression analysis was performed, which demonstrated that the expression of lipocalin2 (LCN2) was elevated upon PKP3 loss and...

journal_title：Experimental cell research

authors： Basu S,Chaudhary N,Shah S,Braggs C,Sawant A,Vaz S,Thorat R,Gupta S,Dalal SN

更新日期：2018-08-15 00:00:00

abstract：:The continuously decreasing willingness for liver donation aggravates treatment of end-stage liver diseases requiring organ transplantation as the only curative strategy. Cell therapy approaches using human hepatocytes or stem cell-derived hepatocyte-like cells may be a therapeutic option out of this dilemma. ABCB5-po...

journal_title：Experimental cell research

authors： Tietze L,Winkler S,Hempel M,Kluth MA,Tappenbeck N,Ganss C,Dooley S,Christ B

更新日期：2018-08-15 00:00:00

abstract：:Human cytomegalovirus (HCMV) has led to kinds of clinical disorders and great morbidity worldwide, such as sensorineural hearing loss (SNHL), mental retardation, and developmental delays in immunocompromised individuals. Congenital HCMV infection is a leading cause of birth defects, primarily manifesting as neurologic...

journal_title：Experimental cell research

authors： He X,Teng J,Cui C,Li D,Wen L

更新日期：2018-08-15 00:00:00

abstract：:Identification of transcription factors expressed by differentiated cells is informative not only of tissue-specific pathways, but to help identify master regulators for cellular reprogramming. If applied, such an approach could generate healthy autologous tissue-specific cells for clinical use where cells from the ho...

journal_title：Experimental cell research

authors： Hustler A,Eardley I,Hinley J,Pearson J,Wezel F,Radvanyi F,Baker SC,Southgate J

更新日期：2018-08-15 00:00:00

abstract：BACKGROUND:CDK8 is associated with the transcriptional Mediator complex and has been shown to regulate several transcription factors implicated in cancer. As a pancreatic cancer oncogene, the role of CDK8 in cancer angiogenesis remains unclear. Here, we investigated the contribution of CDK8 in pancreatic cancer angioge...

journal_title：Experimental cell research

authors： Wei R,Kong L,Xiao Y,Yuan H,Song Y,Wang J,Yu H,Mao S,Xu W

更新日期：2018-08-15 00:00:00

abstract：:The 37 kDa/67 kDa laminin receptor (LRP/LR) is over-expressed in tumor cells and has been implicated in several tumourigenic processes such as metastasis and telomerase activation, however, more importantly the focus of the present study is on the maintenance of cellular viability and the evasion of apoptosis. The aim...

journal_title：Experimental cell research

authors： Rebelo TM,Vania L,Ferreira E,Weiss SFT

更新日期：2018-07-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is one of the most common cancers diagnosed worldwide. However, the mechanism underlying HCC pathogenesis remains unknown. In the present study, TRIM24 was found increased in human HCC clinical samples and positively correlated with HCC tumor grade. Furthermore, TRIM24 knockdown inhibits...

journal_title：Experimental cell research

authors： Zhu Y,Zhao L,Shi K,Huang Z,Chen B

更新日期：2018-06-15 00:00:00

abstract：:Oligodendrocyte precursor cells (OPCs) are needed for white matter repair after various brain injury. Means that promote OPC functions could benefit white matter recovery after injury. Chemokine CXCL12 and endothelial progenitor cells (EPCs) both have been shown to promote remyelination. We hypothesize that the benefi...

journal_title：Experimental cell research

authors： Yuan F,Chang S,Luo L,Li Y,Wang L,Song Y,Qu M,Zhang Z,Yang GY,Wang Y

更新日期：2018-06-15 00:00:00

abstract：:Ossification of the ligamentum flavum (OLF) is a debilitating disease resulting from the development of ectopic bone formation, which leads to the compression of the spinal cord. Nicotinamide phosphoribosyltransferase (NAMPT) was found to be upregulated and microRNA-182 (miR-182) was downregulated in OLF tissue. We in...

journal_title：Experimental cell research

authors： Zhang Q,Shen Y,Jiang Y,Zhao S,Zhou D,Xu N

更新日期：2018-06-15 00:00:00

abstract：:Esophageal squamous cell carcinoma (ESCC) is one of the most malignant tumors in China with a poor prognosis. Most ESCC patients were diagnosed at advanced stages, losing the opportunity for surgical excision. Hence, it remains a pressing work to identify biomarkers for early detection, prognosis prediction and target...

journal_title：Experimental cell research

authors： Yuan H,Zhou W,Yang Y,Xue L,Liu L,Song Y

更新日期：2018-06-01 00:00:00

abstract：:The Golgi apparatus plays roles in cell polarity, directional cell migration, and bipolar spindle assembly, as well as the secretary pathway. In addition, recent studies have suggested the Golgi-dependent control of mitotic entry. We studied the role of the centrosomal kinase Aurora A in maintaining the Golgi apparatu...

journal_title：Experimental cell research

authors： Kimura M,Takagi S,Nakashima S

更新日期：2018-06-01 00:00:00

abstract：:Blood vessels are one of the major routes for the dissemination of cancer cells. Malignant tumors release growth factors such as vascular endothelial growth factor(VEGF) to induce angiogenesis, thereby promoting metastasis. Here, we report that The Drosophila Eyes Absent Homologue 1 (EYA1), which is overexpressed in c...

journal_title：Experimental cell research

authors： Cai S,Cheng X,Liu Y,Lin Z,Zeng W,Yang C,Liu L,Chukwuebuka OA,Li W

更新日期：2018-06-01 00:00:00

abstract：:Breast cancer and prostate cancer are the most common malignant tumors in female and men, respectively. Furthermore, lung cancer is the leading cause of cancer deaths worldwide. It is an emergency to develop a powerful strategy to treat these threatening cancers more effectively, because of low efficacy and high rates...

journal_title：Experimental cell research

authors： Karbasforooshan H,Roohbakhsh A,Karimi G

更新日期：2018-06-01 00:00:00

abstract：:Caveolin-1 (Cav-1) is a principal structural protein of caveolae. Cav-1 has been implicated in cancer progression, but its precise functional roles in pituitary adenoma cells remain largely unclear. In this study, we evidenced that the level of cav-1 was elevated in the invasive pituitary adenoma. Cav-1 knockdown rest...

journal_title：Experimental cell research

authors： Yang W,Xu T,Qiu P,Xu G

更新日期：2018-06-01 00:00:00

abstract：:Chitosan oligosaccharides (COS), linear polymers of N-acetyl-D-glucosamine and deacetylated glucosamine, exhibit diverse pharmacological effects such as antimicrobial, antitumor, antioxidant and anti-inflammatory activities. Here, we explored their hypocholesterolemic effects in vivo and the molecular mechanisms of CO...

journal_title：Experimental cell research

authors： Yang X,Zhang J,Chen L,Wu Q,Yu C

更新日期：2018-05-15 00:00:00

abstract：:Inflammatory cells such as macrophages can play a pro-tumorigenic role in the tumor stroma. Tumor-associated macrophages (TAMs) generally display an M2 phenotype with tumor-promoting activity; however, the mechanisms regulating the TAM phenotype remain unclear. Complement 5a (C5a) is a cytokine-like polypeptide that i...

journal_title：Experimental cell research

authors： Piao C,Zhang WM,Li TT,Zhang CC,Qiu S,Liu Y,Liu S,Jin M,Jia LX,Song WC,Du J

更新日期：2018-05-15 00:00:00

abstract：:Macrophage polarization plays a crucial role in regulating myocardial inflammation and injuries of coxsackievirus B3 (CVB3)-induced viral myocarditis (VM). It has been reported that miR-223 is a potent regulator of inflammatory responses that involved in macrophage polarization. However, the functional roles of miR-22...

journal_title：Experimental cell research

authors： Gou W,Zhang Z,Yang C,Li Y

更新日期：2018-05-01 00:00:00

abstract：:The ATP/P2X7 axis of dendritic cells (DCs) mediates the activation of NLRP3 inflammasome and promotes secretion of interleukin (IL)-1β and IL-18 to induce T helper (Th) 2, Th17 differentiation in the pathogenesis of asthma. NLRP3 inflammasome also regulates high mobility protein 1 (HMGB1) release in DCs. Recent studie...

journal_title：Experimental cell research

authors： Li R,Wang J,Li R,Zhu F,Xu W,Zha G,He G,Cao H,Wang Y,Yang J

更新日期：2018-05-01 00:00:00

abstract：:TLR expression in neutrophils and monocytes is associated with increased cytokine synthesis, resulting in increased inflammation. However, the inflammatory pathway related to TLR and cathelicidin expression in these cells from CKD patients is unclear. To evaluate TLR4, cathelicidin, TNF-α, IL-6, IL-10 and MCP-1 expres...

journal_title：Experimental cell research

authors： Grabulosa CC,Manfredi SR,Canziani ME,Quinto BMR,Barbosa RB,Rebello JF,Batista MC,Cendoroglo M,Dalboni MA

更新日期：2018-04-15 00:00:00

abstract：:Angiogenesis is a process encompassing several steps such as endothelial cells proliferation, differentiation and migration to form a vascular network, involving different signal transduction pathways. Among these, ERK1/2 signaling mediates VEGF-dependent signaling pathway. Here we report that the water extract of Rut...

journal_title：Experimental cell research

authors： Gentile MT,Russo R,Pastorino O,Cioffi S,Barbieri F,Illingworth EA,Grieco M,Chambery A,Colucci-D'Amato L

更新日期：2018-03-01 00:00:00

abstract：:TGFβ contributes to mesangial cell hypertrophy and matrix protein increase in various kidney diseases including diabetic nephropathy. Deptor is an mTOR-interacting protein and suppresses mTORC1 and mTORC2 activities. We have recently shown that TGFβ-induced inhibition of deptor increases the mTOR activity. The mechani...

journal_title：Experimental cell research

authors： Maity S,Bera A,Ghosh-Choudhury N,Das F,Kasinath BS,Choudhury GG

更新日期：2018-03-01 00:00:00

abstract：:The poor outcome of hepatocellular carcinoma (HCC) is mainly due to the development of fast growth, invasion and metastasis. The role of TET2 has been implicated in some cancer types, but its role and mechanisms in HCC remains elusive. In this study, our findings indicated that TET2 expression frequently increased in ...

journal_title：Experimental cell research

authors： Yang G,Zeng X,Wang M,Wu A

更新日期：2018-02-15 00:00:00

abstract：:The liver plays critical roles in both homeostasis and pathology. It is the major site of drug metabolism in the body and, as such, a common target for drug-induced toxicity and is susceptible to a wide range of diseases. In contrast to other solid organs, the liver possesses the unique ability to regenerate. The phys...

journal_title：Experimental cell research

authors： Beckwitt CH,Clark AM,Wheeler S,Taylor DL,Stolz DB,Griffith L,Wells A

更新日期：2018-02-01 00:00:00

abstract：:Erectile dysfunction (ED) is the most common sexual disorder that men report to healthcare providers. Gap junctions (GJs) are thought to be responsible for synchronous shrinkage of corpus cavernosum smooth muscle cells (CCSMCs), and play thus an important role in the maintenance of an erection. Hypoxia has been sugges...

journal_title：Experimental cell research

authors： Zhang X,Zhao F,Zhao JF,Fu HY,Huang XJ,Lv BD

更新日期：2018-01-15 00:00:00

abstract：:RalGPS2 is a Ras-independent Guanine Nucleotide Exchange Factor (GEF) for RalA containing a PH domain and an SH3-binding region and it is involved in several cellular processes, such as cytokinesis, control of cell cycle progression, differentiation, cytoskeleton organization and rearrangement. Up to now, few data hav...

journal_title：Experimental cell research

authors： D'Aloia A,Berruti G,Costa B,Schiller C,Ambrosini R,Pastori V,Martegani E,Ceriani M

更新日期：2018-01-15 00:00:00

abstract：:Mitochondria are increasingly recognized as key mediators of acute cellular stress responses in asthma. However, the distinct roles of regulators of mitochondrial physiology on allergic asthma phenotypes are currently unknown. The mitochondrial Ca2+ uniporter (MCU) resides in the inner mitochondrial membrane and contr...

journal_title：Experimental cell research

authors： Sebag SC,Koval OM,Paschke JD,Winters CJ,Comellas AP,Grumbach IM

更新日期：2018-01-15 00:00:00

abstract：:Serelaxin, a recombinant form of human relaxin-2, is currently regarded as a novel drug for treatment of acute heart failure. However, whether therapeutic effects of serelaxin are achieved by inhibiting cardiac fibrosis remains unclear. In this study, we investigate effects of serelaxin on inhibiting cardiac fibrosis....

journal_title：Experimental cell research

authors： Wu XP,Wang HJ,Wang YL,Shen HR,Tan YZ

更新日期：2018-01-01 00:00:00

abstract：:Several species of Streptococcus, such as S. salivarius, S. mitis, and S. anginosus, are found to extensively colonize the oral cavity and the upper respiratory tract, and have been shown to increase in patients with oral squamous cell carcinoma (OSCC). Accumulating evidence have revealed that commensal bacteria are i...

journal_title：Experimental cell research

authors： Wang J,Sun F,Lin X,Li Z,Mao X,Jiang C

更新日期：2018-01-01 00:00:00

abstract：:Pluripotent stem cell activity is essential to maintain regeneration and homeostasis in the Drosophila midgut following environmental challenges. Although multiple pathways have been implicated in epithelial renewal, the underlying regulatory mechanisms and correlations between relevant genes and pathways remain elusi...

journal_title：Experimental cell research

authors： Liu Q,Jin LH

更新日期：2017-12-15 00:00:00

abstract：:Deregulation of the bone morphogenetic protein (BMP) pathway has been documented in colorectal cancer (CRC). Previously, we investigated possible associations between urokinase-type plasminogen activator (uPA) deficiency and expression of extracellular constituents of BMP signaling in a newly developed mouse model of ...

journal_title：Experimental cell research

authors： Afaloniati H,Karagiannis GS,Hardas A,Poutahidis T,Angelopoulou K

更新日期：2017-12-15 00:00:00

abstract：:Gastric cancer tissue-derived mesenchymal stem cells (GC-MSCs) are important resident stromal cells in the tumor microenvironment (TME) and have been shown to play a key role in gastric cancer progression. Whether GC-MSCs exert a tumor-promoting function by affecting anti-tumor immunity is still unclear. In this study...

journal_title：Experimental cell research

authors： Wang M,Chen B,Sun XX,Zhao XD,Zhao YY,Sun L,Xu CG,Shen B,Su ZL,Xu WR,Zhu W

更新日期：2017-12-01 00:00:00